Process adaptation in fermentation based biomanufacturing

• reactor designs (the hardware)
• reactor operating modes
• mass balances related to the different operating modes
• suspended growth systems vs. immobilized growth systems (biofilms)
• miniaturized reactor systems for high throughput fermentation
• scale-up and scale-down of a process
• on-line sensors (both traditional and novel systems) and biosensors
• basic bioreactor control concepts
• on-line process control
• introduction to computational fluid dynamics and compartment models
• data (types of data, on-line versus off-line), proper handling of data
• different ways to use the available data (estimate parameters in a mechanistic model, extract process knowledge)
• basic concepts of artificial intelligence applied to fermentation data

The main purpose of this course is to introduce students to the methods and tools that are used when transferring a cell from a lab or research environment to pilot and full scale. The student following this course should therefore acquire a better understanding of the interactions between the cells and the hardware (the reactor), and will learn how to aim for optimal conditions for the cells to grow in large scale. The lectures will be given by experienced DTU teachers, combined with guest teachers from industry. The course includes visits to the pilot plant of DTU Chemical Engineering and to industry (e.g. pilot plant environment).

Lectures, problem solving, simulation exercises (Python and Matlab/Simulink)